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Apixaban is a highly selective direct factor Xa inhibitor, blocking the propagation phase of the coagulation cascade. It exerts its effect on both free and clot-bound factor Xa. For antithrombotic activity, it does not need antithrombin III. Factor Xa is a catalyst for the conversion of prothrombin to thrombin, which is the final step in the coagulation cascade leading to fibrin and clot formation.[9] Other direct factor Xa inhibitors include rivaroxaban and edoxaban. 2ff7e9595c
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